About to make my first VN, any side themes you want to see that havent been touched or exploited a lot?

Put in a male who outwardly appears as female via crossdressing, and have him display shyness, low self esteem, and an insatiable desire for skin to skin contact with other human beings.

Have his obsessive neediness and anxiety be MASSIVE burdens that get thoroughly in the way of fixing any of this problems, making the player feel like any interaction with him is an uphill struggle against the crossdresser's own mental health issues.

Good end route involves the man letting go of his shyness, low self esteem, becoming happy and confident and chasing his dreams. He no longer has a desperate obsessive need for skin to skin contact. He'll take it if the opportunity comes up but if it doesn't come up it's no big deal because he's comfortable with his life. He also stops crossdressing.

Bad end has him wrestle with his personal neuroses and phobias and lose, becoming even MORE shy and desperate, so much so that the player cannot stand his presence and the player leaves. The young man realises that he has missed his last shot at any real human companionship and he's getting uglier and less cute with every passing year, so he kills himself.

cuckoldry but its revealed that the guy watching wants to fuck you and not the chick, and then it turns into a threesome

Lolis desperately craving after mommy futa dick

>Prostitution
Ah cool.
So indentured servitude, or people who opt to go into prostitution because their family is hungry?
Stonk empowered women who are owning their body and their choices and getting fuckin RICH for very little effort to fund their dreams?
The seedy world of online camsluts who have paid private rooms, and the money laundering they tend to get up to?
Pimping, protection, territorial control, sex as a commodity, and the non-easiness of said pimping?

Not really my type of thing but I can get behind it. So you're looking for ideas for the Johns?
Tired older businesswoman who REALLY fucking hates her job but who sticks to it because she's like a mother to those lazy entitled retards she's a boss off and she's going to wrangle those tards into productivity and drag them kicking and screaming into being good workers.
Takes the same attitude towards the player. Dominant, strict, and with high standards. But well-paying, wants you to be good at your job, and caring in her own way.